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产品信息
PA5-77052
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human ASIP.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720779
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: agouti signaling protein, nonagouti homolog; Agouti switch protein; Agouti-signaling protein; ASP; nonagouti homolog
基因别名: AGSW; AGTI; AGTIL; ASIP; ASP; SHEP9
UniProt ID: (Human) P42127
Entrez Gene ID: (Human) 434
generation of precursor metabolites and energy
signal transduction
cell-cell signaling
adult feeding behavior
hormone-mediated signaling pathway
melanosome transport
melanosome organization
regulation of molecular function, epigenetic
melanin biosynthetic process
positive regulation of melanin biosynthetic process
genetic imprinting
