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产品信息
PA5-72945
产品规格
种属反应
Human,
Mammal,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a region of human ATF3 (within residues 100-150). [UniProt# P18847]
偶联物
形式
Liquid
浓度
1.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 30% glycerol
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2718799
靶标信息
ATF3 (Activating transcription factor 3) is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. It encodes a protein with a calculated molecular mass of 22 kD. ATF3 represses rather than activates transcription from promoters with ATF binding elements. An alternatively spliced form of ATF3 (ATF3 delta Zip) encodes a truncated form ATF3 protein lacking the leucine zipper protein-dimerization motif and does not bind to DNA. In contrast to ATF3, ATF3 delta Zip stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes. Three transcript variants encoding two different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activating transcription factor 3; ATF 3; cAMP-dependent transcription factor ATF-3; Cyclic AMP-dependent transcription factor ATF-3; Liver regeneration factor 1; LRF-1; Transcription factor LRG-21
基因别名: ATF3; LRF-1; Lrf1; LRFI; LRG-21
UniProt ID: (Human) P18847, (Mouse) Q60765, (Rat) P29596
Entrez Gene ID: (Human) 467, (Mouse) 11910, (Rat) 25389
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
identical protein binding
protein homodimerization activity
transcription regulatory region DNA binding
protein heterodimerization activity
DNA binding
sequence-specific DNA binding
basic leucine zipper transcription factor
negative regulation of transcription from RNA polymerase II promoter
gluconeogenesis
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
cellular response to amino acid starvation
skeletal muscle cell differentiation
PERK-mediated unfolded protein response
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
negative regulation of ERK1 and ERK2 cascade
positive regulation of TRAIL-activated apoptotic signaling pathway
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
endoplasmic reticulum unfolded protein response
negative regulation of transcription, DNA-templated
cell fate determination
