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ATG16L1 Antibody (PA5-35207) in ICC/IF
Immunocytochemistry analysis of ATG16L1 in U251 cells. Samples were incubated with ATG16L1 polyclonal antibody (Product # PA5-35207) using a dilution of 1:25 followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG at a dilution of 1:400 (green). Cells (right) were treated with Chloroquine (50 μM, 16hr). DAPI was used to stain the cell nuclear (blue).
产品信息
PA5-35207
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 161-190 amino acids from human ATG16L
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2552517
靶标信息
Autophagy related protein 16 L is encoded by the ATG16L gene and is located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10). ATG 12 and ATG5 conjugate with each other and undergoes homo oligomerisation with ATG16L to form an 800 kDa complex called the Atg16L complex. This complex facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE) and this ubiquitin-like conjugation system is a widely used marker for autophagy. However, the ATG 16L complex along with other ATGs like ATG 18 and ATG 21 prevent the premature cleavage of ATG8-PE by the cysteine protease, Atg4 until the autophagosome is deemed complete.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A16L1; APG 16-L1; APG16-like 1; APG16L beta; APG16L isoforms 1; atg16; ATG16 autophagy related 16-like 1; Atg16L1 gamma; autophagy related 16-like 1; autophagy-related 16-like 1 gamma; Autophagy-related protein 16-1; hCG_1817841; WD repeat domain 30
基因别名: 1500009K01Rik; APG16L; ATG16A; ATG16L; ATG16L1; IBD10; UNQ9393/PRO34307; WDR30
UniProt ID: (Human) Q676U5, (Mouse) Q8C0J2
Entrez Gene ID: (Human) 55054, (Mouse) 77040
