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Recommended positive controls: A549, H1299, HCT116, mouse white adipose.
Predicted reactivity: Mouse (83%), Rat (83%), Pig (80%), Sheep (85%), Bovine (84%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Adipose triglyceride lipase; ATGL DESNUTRIN; calcium-independent phospholipase A2; Calcium-independent phospholipase A2-zeta; Desnutrin; DKFZp667M109; IPLA2 zeta; IPLA2-zeta; mutant patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing protein 2; Patatin-like phospholipase domain-containing protein 2; PEDF R; PEDF-R; pigment epithelium-derived factor; Pigment epithelium-derived factor receptor; plpl; plpl2; transport-secretion protein; Transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS 2.2; TTS2; TTS2.2
基因别名: 0610039C21Rik; 1110001C14Rik; ATGL; FP17548; iPLA2zeta; PEDF-R; PNPLA2; TTS-2.2; TTS2
UniProt ID: (Human) Q96AD5, (Mouse) Q8BJ56
Entrez Gene ID: (Human) 57104, (Mouse) 66853