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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci that contain the DNA repair protein Rad51. ATMIN is also thought to be involved in embryonic development, as an absence of ATMIN causes late-embryonic lethality in mice with a range of organ development defects. It also activates the transcription DYNLL1, a light chain of the dynein motor complex and sequence-specific regulator of protein dimerization of numerous targets. DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a simple dynamic feedback loop for DYNLL1 expression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ASCIZ; ATM INteracting protein; ATM interactor; ATM/ATR-substrate CHEK2-interacting zinc finger protein; ATM/ATR-substrate CHK2-interacting zinc finger protein; ATM/ATR-Substrate Chk2-Interacting Zn++-finger protein; ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein; atmin; Zinc finger protein 822
基因别名: ASCIZ; ATMIN; gpg6; KIAA0431; mKIAA0431; RGD1305781; ZNF822
UniProt ID: (Human) O43313, (Mouse) Q6P9S1
Entrez Gene ID: (Human) 23300, (Rat) 315037, (Mouse) 234776