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Invitrogen

ATP1A2 Recombinant Rabbit Monoclonal Antibody (ARC2458)

查看其他4个ATP1A2抗体
说明书
实验方案
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说明书
实验方案
技术支持

产品信息

MA5-37905

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:2,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

ARC2458

抗原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ATP1A2 (P50993)
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偶联物

Unconjugated

形式

Liquid

浓度

0.8 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2897825

产品详细信息

Positive Samples: Mouse heart, Mouse skeletal muscle, Rat heart

Immunogen sequence: MGRGAGREYS PAATTAENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG RKYQVDLSKG LTNQRAQDVL ARDGPNALTP PPTTPEWVKF CRQLFGGFSI

靶标信息

Atp1a2 encodes an Na+/K+ ATPase, which is a membrane protein that is composed of two subunits - alpha and beta. The Na+/K+ ATPase pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions. The Atp1a2 encoded protein belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These ion gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. The ATPase enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta), and the catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. The Atp1a2 gene encodes an alpha 2 subunit. Mutations in the Atp1a2 gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. Diseases associated with ATP1A2 include Alternating Hemiplegia Of Childhood and Migraine, Familial Hemiplegic, 2.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ATPase, Na+K+ transporting, alpha 2; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; Sodium Potassium ATPase; Sodium pump subunit alpha-2; Sodium/potassium-transporting ATPase subunit alpha-2

基因别名: Atp1a2; Atpa-3; AW060654; mKIAA0778; RATATPA2

UniProt ID: (Rat) P06686, (Mouse) Q6PIE5

Entrez Gene ID: (Rat) 24212, (Mouse) 98660

功能
sodium:potassium-exchanging ATPase activity protein binding ATP binding cation-transporting ATPase activity metal ion binding chaperone binding steroid hormone binding nucleotide binding hydrolase activity primary active transporter
参与通路
neurotransmitter uptake regulation of the force of heart contraction regulation of respiratory gaseous exchange by neurological system process potassium ion transport sodium ion transport cellular sodium ion homeostasis regulation of muscle contraction regulation of smooth muscle contraction regulation of striated muscle contraction metabolic process regulation of blood pressure adult locomotory behavior visual learning potassium ion import regulation of cardiac muscle contraction by calcium ion signaling energy coupled proton transmembrane transport, against electrochemical gradient ATP hydrolysis coupled proton transport regulation of vasoconstriction cellular potassium ion homeostasis response to nicotine sodium ion export from cell locomotion negative regulation of heart contraction negative regulation of striated muscle contraction negative regulation of cytosolic calcium ion concentration relaxation of cardiac muscle cardiac muscle contraction cellular response to mechanical stimulus cellular response to steroid hormone stimulus regulation of cardiac muscle cell contraction negative regulation of calcium ion transmembrane transport negative regulation of calcium:sodium antiporter activity response to glycoside transport ion transport
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