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Immunogen sequence: KPTYQDRVAP PGLTQIPQIQ KTEISFRPND PKSYEAYVLN IVRFLEKYKD SAQRDDMIFE DCGDVPSEPK ERGDFNHERG ERKVCRFKLE WLGNCSGLND ETYGYKEGKP CIIIKLNRVL GFKPKPPKNE SLETYPVMKY NPNVLPVQCT GKRDEDKDKV GNVEYFGLGN SPGFPL; Positive Samples: U-251MG, Mouse brain, Mouse liver, Mouse kidney, Rat kidney, Rat brain; Cellular Location: Cell membrane, Single-pass type II membrane protein
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: adenosinetriphosphatase; ATPase, Na+/K+ transporting, beta 1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; MGC1798; Na+/K+ ATPase Beta; Na, K-ATPase beta-1 polypeptide; Na,K-ATPase beta 1 subunit; OTTHUMP00000032537; OTTHUMP00000032538; Sodium Potassium ATPase; sodium pump subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); sodium/potassium ATPase beta subunit; sodium/potassium-dependent ATPase beta-1 subunit; Sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase beta-1 chain; Sodium/potassium-transporting ATPase subunit beta-1
基因别名: ATP1B; ATP1B1; Atp4b; Atpb; Atpb-1; ATPBS; NKbeta1
UniProt ID: (Human) P05026, (Rat) P07340, (Mouse) P14094
Entrez Gene ID: (Human) 481, (Rat) 25650, (Mouse) 11931
分子生物学功能: primary active transporter