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产品信息
PA5-66027
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2664389
产品详细信息
Immunogen sequence: VKCGYFYLEFA ETGSVKDFGI QPVEDKGACR LPLCSLPGEP GNGPDQQLQR SPPEFQ
Highest antigen sequence identity to the following orthologs - mouse 89%, rat 93%.
靶标信息
By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ataxin 7-like 3B; Ataxin-7-like protein 3B
基因别名: ATXN7L3B; lnc-SCA7
UniProt ID: (Human) Q96GX2
Entrez Gene ID: (Human) 552889
