Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
H00000566-B01P
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AZU1 (NP_001691.1, 1 a.a. approximately 251 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTRLTVLALL AGLLASSRAG SSPLLDIVGG RKARPRQFPF LASIQNQGRH FCGGALIHAR FVMTAASCFQ SQNPGVSTVV LGAYDLRRRE RQSRQTFSIS SMSENGYDPQ QNLNDLMLLQ LDREANLTSS VTILPLPLQN ATVEAGTRCQ VAGWGSQRSG GRLSRFPRFV NVTVTPEDQC RPNNVCTGVL TRRGGICNGD GGTPLVCEGL AHGVASFSLG PCGRGPDFFT RVALFRDWID GVLNNPGPGP A
靶标信息
Azurocidin, also called heparin-binding protein (HBP), is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to have only activity against gram-negative bacteria. Later it was also found to act against gram-positive bacteria and C. albicans. Azurocidin is considered a family member of polymorphonuclear leukocytes- derived antimicrobial proteins like defensins, LL-37 and lysozyme. Azurocidin has been recognized as a player in the activation and modulation of the immune response and may act to alarm the immune system. The cationic domain at one side of the protein is essential for its antimicrobial activity. It is stored in azurophil granules as well as secretory granules and as a result partly released at early stage of extravasation. Azurocidin is involved in chemotaxis and activation of monocytes, cytokine release and phagocytosis leading to more efficient bacterial clearance. The primary targeted environment of azurocidin are cells in the bloodstream, that is the endothelial lining, and the extravascular surroundings. The interaction of azurocidin with leucocytes is mediated via beta 2-intergrins. High plasma levels of azurocidin might help with the identification of patients which are at risk in developing sepsis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Azurocidin; cationic antimicrobial protein 37; Cationic antimicrobial protein CAP37; HBP; Heparin-binding protein; neutrophil azurocidin
基因别名: AZAMP; AZU; AZU1; CAP37; HBP; hHBP; HUMAZUR; NAZC
UniProt ID: (Human) P20160
Entrez Gene ID: (Human) 566
microglial cell activation
proteolysis
inflammatory response
protein kinase C-activating G-protein coupled receptor signaling pathway
glial cell migration
positive regulation of gene expression
positive regulation of peptidyl-threonine phosphorylation
protein processing
antimicrobial humoral response
calcium-mediated signaling using intracellular calcium source
monocyte activation
positive regulation of tumor necrosis factor biosynthetic process
negative regulation of apoptotic process
regulation of vascular permeability
cellular extravasation
positive regulation of MHC class II biosynthetic process
positive regulation of cell adhesion
positive regulation of protein kinase activity
macrophage chemotaxis
positive regulation of interleukin-1 beta biosynthetic process
positive regulation of fractalkine biosynthetic process
positive regulation of phagocytosis
defense response to Gram-negative bacterium
induction of positive chemotaxis
defense response to virus
cell chemotaxis
protein kinase C signaling
neutrophil mediated killing of bacterium
