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Aldolase B Antibody (PA5-116491) in IHC (P)
Immunohistochemical analysis of Aldolase B in a paraffin-embedded mouse small intestine tissue using a Aldolase B polyclonal antibody (Product #PA5-116491). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antib... View More
产品信息
PA5-116491
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein within Human Aldolase B aa 1-189
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2901122
产品详细信息
Positive controls: SH-SY5Y lysate, human liver tissue lysate, mouse liver tissue lysate, mouse kidney tissue lysate, rat kidney tissue, human liver tissue, human kidney tissue, mouse small intestine tissue, SH-SY5Y.
靶标信息
Fructose-1,6-bisphosphate aldolase is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aldolase 2; aldolase 2, B isoform; Aldolase B fructose-biphosphate; Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphatase; aldolase B, fructose-bisphosphate; Fructose-bisphosphate aldolase B; Liver-type aldolase
基因别名: ALDB; Aldo-2; ALDO2; ALDOB; BC016435; LIV10
UniProt ID: (Human) P05062, (Mouse) Q91Y97
Entrez Gene ID: (Human) 229, (Mouse) 230163, (Rat) 24190
liver development
fructose metabolic process
gluconeogenesis
glycolytic process
NADH oxidation
response to fructose
response to zinc ion
fructose 1,6-bisphosphate metabolic process
cellular response to extracellular stimulus
positive regulation of ATPase activity
cellular response to insulin stimulus
response to drug
response to starvation
response to amino acid
response to copper ion
response to glucocorticoid
response to cAMP
canonical glycolysis
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
vacuolar proton-transporting V-type ATPase complex assembly
response to interleukin-6
response to peptide hormone
response to carbohydrate
response to organic cyclic compound
