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Aldolase B Antibody (PA5-30218) in IHC (P)
Aldolase B Polyclonal Antibody detects ALDOB protein at cytosol on human hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded hepatoma tissue. Aldolase B Polyclonal Antibody (Product # PA5-30218) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-30218
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 84 and 288 of Human Aldolase B
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547692
产品详细信息
Recommended positive controls: 293T, A431, Jurkat, Raji, mouse liver, PC-12, Rat2, mouse brain, rat brain.
Predicted reactivity: Human (99%), Mouse (96%), Rat (96%), Zebrafish (82%), Rabbit (98%), Chicken (84%), Sheep (93%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Fructose-1,6-bisphosphate aldolase is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Aldolase 2; aldolase 2, B isoform; Aldolase B fructose-biphosphate; Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphatase; aldolase B, fructose-bisphosphate; Fructose-bisphosphate aldolase B; Liver-type aldolase
基因别名: ALDB; Aldo-2; ALDO2; ALDOB; BC016435; LIV10
UniProt ID: (Human) P05062, (Mouse) Q91Y97
Entrez Gene ID: (Human) 229, (Mouse) 230163, (Rat) 24190
liver development
fructose metabolic process
gluconeogenesis
glycolytic process
NADH oxidation
response to fructose
response to zinc ion
fructose 1,6-bisphosphate metabolic process
cellular response to extracellular stimulus
positive regulation of ATPase activity
cellular response to insulin stimulus
response to drug
response to starvation
response to amino acid
response to copper ion
response to glucocorticoid
response to cAMP
canonical glycolysis
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
vacuolar proton-transporting V-type ATPase complex assembly
response to interleukin-6
response to peptide hormone
response to carbohydrate
response to organic cyclic compound
