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Invitrogen
Angiogenin Polyclonal Antibody
高级验证
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
产品信息
PA5-89249
产品规格
种属反应
Rat,
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 25-147 of human ANG (NP_0011361)
偶联物
形式
Liquid
浓度
2.92 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805443
产品详细信息
Immunogen sequence: QDNSRYTHFL TQHYDAKPQG RDDRYCESIM RRRGLTSPCK DINTFIHGNK RSIKAICENK NGNPHRENLR ISKSSFQVTT CKLHGGSPWP PCQYRATAGF RNVVVACENG LPVHLDQSIF RRP; Positive Samples: LO2, HeLa, NCI-H460, B cells, Mouse liver, Rat liver; Cellular Location: Nucleus, basement membrane, extracellular matrix, extracellular space, nucleolus
靶标信息
Angiogenin (ANG or ANG I) is important for the process of neovascularization and formation of new blood vessels. ANG is similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. It interacts with endothelial cell-surface actin and may cause changes in the cell cytoskeleton. ANG is thought to be involved in the development of solid tumors and its antagonists are capable of inhibiting tumor growth. Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9). Angiogenin is a genetic link between ALS and PD.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Angiogenin; angiogenin ribonuclease 1; angiogenin, ribonuclease A family, member 1; angiogenin, ribonuclease, RNase A family, 5; Angiogenin-1; epididymis luminal protein 168; MGC22466; MGC71966; Ribonuclease 5; ribonuclease A A1; ribonuclease A family member 5; RNase 5
基因别名: AI385586; ALS9; ANG; Ang1; HEL168; RAA1; RNASE4; RNASE5; Rnase5a
UniProt ID: (Human) P03950, (Mouse) P21570
Entrez Gene ID: (Human) 283, (Mouse) 11727, (Rat) 305843
angiogenesis
response to hypoxia
positive regulation of endothelial cell proliferation
diacylglycerol biosynthetic process
activation of phospholipase C activity
multicellular organism development
central nervous system development
rRNA transcription
response to hormone
cell migration
negative regulation of translation
cell differentiation
activation of protein kinase B activity
activation of phospholipase A2 activity
positive regulation of phosphorylation
negative regulation of smooth muscle cell proliferation
positive regulation of protein secretion
nucleic acid phosphodiester bond hydrolysis
RNA phosphodiester bond hydrolysis
liver development
ovarian follicle development
oocyte maturation
response to yeast
placenta development
cell communication
antibacterial humoral response
antifungal humoral response
actin filament polymerization
adherens junction organization
homeostatic process
innate immune response
defense response to Gram-positive bacterium
