Invitrogen

Apolipoprotein J Monoclonal Antibody (D18)

Apolipoprotein J Antibody in Western Blot (WB)

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Apolipoprotein J Antibody (MA5-41566) in WB

Western blot analysis of Apolipoprotein J in Porcine Serum. Samples were incubated with monoclonal antibody (Product # MA5-41566) at a dilution of 3 µg/mL.

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产品信息

MA5-41566

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.5-2 µg/mL

免疫组化（石蜡） (IHC (P))

5-20 µg/mL

免疫细胞化学 (ICC/IF)

5-20 µg/mL

产品规格

种属反应

Pig

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

D18

抗原

Recombinant protein Clusterin. The antigen corresponds to amino acid range 229-446 of the target protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2899048

靶标信息

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Aging associated protein 4; apo j; Apo J a; Apo J alpha; Apo J b; Apo J beta; Apo J α; Apo J β; Apo Ja; Apo Jb; ApoJ a; ApoJ alpha; ApoJ b; ApoJ beta; ApoJ α; ApoJ β; ApoJa; ApoJb; CLI; Clusterin; Clusterin alpha / beta chain; Complement associated protein SP40; Complement cytolysis inhibitor; CP40; GP80; HGNC:2095; Ku70-binding protein 1 (KUB1); MGC24903; Sulfated glycoprotein 2 (SGP2); Testosterone repressed prostate message 2 (TPRM2B)

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基因别名: CLU

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UniProt ID: (Pig) Q29549

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Entrez Gene ID: (Pig) 397025

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功能

beta-amyloid binding protein binding ATPase activity ubiquitin protein ligase binding macromolecular complex binding tau protein binding low-density lipoprotein particle receptor binding unfolded protein binding misfolded protein binding

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