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产品信息
PA5-36535
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 110-160 of human AQP0
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553576
产品详细信息
This antibody detects endogenous protein at a molecular weight of 28 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells where it functions not only as a water pore, but it is also involved in fiber-fiber adhesion and is crucial for fiber cell structure and organization. AQP0 contains an additional pore constriction, not seen in any other aquaporin structures, which may be responsible for pore gating. The closed AQP0 pore holds just three water molecules, which are spaced too far apart to form hydrogen bonds with each other. The C-terminal domain of AQP0 undergoes extensive post-translational modification, including many truncations, during lens aging due to the actions of m-calpain, proteases or non-enzymatic mechanisms. These truncation sites may be involved in the development of cataracts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aquaporin 0; Aquaporin-0; Aquaporin0; dominant cataract; hydropic fibers; Lens fiber major intrinsic protein; lens opacity; major intrinsic protein of eye lens fiber; MIP26; MP26
基因别名: AQP0; Cat; CTRCT15; Hfi; LIM1; Lop; MIP; MIP26; MP26; Palm; shrivelled; Svl
UniProt ID: (Human) P30301, (Mouse) P51180
Entrez Gene ID: (Human) 4284, (Mouse) 17339, (Rat) 25480
lens development in camera-type eye
water transport
visual perception
cellular water homeostasis
canalicular bile acid transport
glycerol transport
ion transmembrane transport
positive regulation of cell adhesion
response to stimulus
protein homotetramerization
gap junction-mediated intercellular transport
transport
cell communication
carbohydrate transmembrane transport
transmembrane transport
