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产品信息
PA5-120182
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human Aromatase (CYP19A1) (NP_000094.2).
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2913754
产品详细信息
Positive test controls include: HeLa, Rat brain. The target is usually found in the following locations: Membrane, Peripheral membrane protein.
Immunogen sequence: MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS SSMFHIMKHN HYSSRFGSKL GLQCIGMHEK GIIFNNNPEL WKTTRPFFMK ALSGPGLVRM VTVCAESLKT HLDRLEEVTN
靶标信息
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aromatase; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; cytochrome P450 family 19 subfamily a; Cytochrome P450, 19, aromatase; cytochrome P450, family 19, subfamily A, polypeptide 1; cytochrome P450, subfamily 19; cytochrome P450, subfamily XIX (aromatization of androgens); Estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; MGC104309; microsomal monooxygenase; P-450AROM
基因别名: ARO; ARO1; Aromatase; CPV1; CYAR; CYP19; Cyp19a; CYP19A1; CYPXIX; P-450AROM; p450arom
UniProt ID: (Human) P11511
Entrez Gene ID: (Human) 1588, (Rat) 25147
iron ion binding
steroid hydroxylase activity
electron carrier activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxygen binding
heme binding
aromatase activity
oxygenase
negative regulation of chronic inflammatory response
steroid biosynthetic process
estrogen biosynthetic process
androgen metabolic process
negative regulation of macrophage chemotaxis
sterol metabolic process
oxidation-reduction process
prostate gland growth
luteinization
bile acid metabolic process
C21-steroid hormone metabolic process
male gonad development
response to herbicide
response to metal ion
response to cesium ion
response to ionizing radiation
response to organic cyclic compound
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phthalate metabolic process
hippocampus development
hypothalamus development
melatonin metabolic process
adrenal gland development
granulocyte differentiation
response to estradiol
response to testosterone
progesterone metabolic process
response to drug
response to morphine
response to estrogen
cellular response to fibroblast growth factor stimulus
negative regulation of bone resorption
regulation of synapse structure or activity
bone development
cellular response to glucose stimulus
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to hydrostatic pressure
