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Alomone Labs, LTD
B1 Bradykinin Receptor (BDKRB1) Polyclonal Antibody
Application
图: 1 / 2
B1 Bradykinin Receptor (BDKRB1) Antibody (ABR-011-200UL) in IHC (F)
Expression of B1bradykinin receptorin rat CNS - Immunohistochemical staining of frozen rat brainsection (A & B) and cerebellum (C) using Anti-B1Bradykinin Receptor (BDKRB1) Antibody (#ABR-011), (1:50). BKR1is expressed in neuronal cells of the amygdala (A) and hippocampus (CA1) (B) as well as in the axons of Purkinje cells in the cerebellum (arrowheads on C). Hoechst 33342 is used as the counterstain.
产品信息
ABR-011-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KEAS RTR*SG GPKGS K, corresponding to amino acid residues 243-257 of rat B1R with replacement of cysteine 250 (C250) with serine (*S), 3rd intracellular loop
偶联物
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B1 bradykinin receptor; B1R; Bk b1 receptor; BK-1 receptor; BKRB1; bradykinin B1 receptor; bradykinin receptor, beta 1; KB1; kinin B1; Kinin B1 receptor
基因别名: B1BKR; B1R; Bdkrb; Bdkrb1; BKR; BKR1; BRADYB1
UniProt ID: (Rat) P97583, (Mouse) Q61125
Entrez Gene ID: (Rat) 81509, (Mouse) 12061
negative regulation of protein phosphorylation
positive regulation of leukocyte migration
inflammatory response
G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
response to mechanical stimulus
cell migration
sensory perception of pain
negative regulation of cell growth
response to lipopolysaccharide
negative regulation of blood pressure
positive regulation of release of sequestered calcium ion into cytosol
response to stress
signal transduction
