Invitrogen

B4GALT1 Polyclonal Antibody

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B4GALT1 Antibody (PA5-106617) in WB

Western blot analysis of B4GALT1 in extracts from 293 cells (LPS 4h treatment). Samples were incubated with B4GALT1 polyclonal antibody (Product # PA5-106617). The lane on the left was treated with blocking peptide.

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产品信息

PA5-106617

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human B4GALT1(Accession P15291), corresponding to amino acid residues L321-L371.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2854285

产品详细信息

Antibody detects endogenous levels of total B4GALT1.

靶标信息

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: b1,4-Galactosyltransferase I; Beta-1,4-galactosyltransferase 1; Beta-1,4-GalTase 1; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; galactosyltransferase 2 beta 1, 4; glycoprotein galactosyltransferase beta 1, 4; glycoprotein-4-beta-galactosyltransferase 2; Golgi complex; lactose synthase; Lactose synthase A protein; N-acetyllactosamine synthase; Nal synthase; Neolactotriaosylceramide beta-1,4-galactosyltransferase; Processed beta-1; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1

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基因别名: B-1,4-GalT; B-1,4-GalT1; B4GAL-T1; B4GALT1; beta-1,4-GalT; beta-1,4-GalT1; beta4Gal-T1; CDG2D; GalT; Ggtb; GGTB2; GT1; GTB

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UniProt ID: (Human) P15291, (Mouse) P15535

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Entrez Gene ID: (Human) 2683, (Mouse) 14595

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