Invitrogen

B4GALT1 Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他7个B4GALT1抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

B4GALT1 Antibody in Immunohistochemistry (IHC)

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B4GALT1 Antibody (PA5-52744) in IHC

Immunohistochemical staining of B4GALT1 in human cerebral cortex, liver, prostate and testis using B4GALT1 Polyclonal Antibody (Product # PA5-52744) (A) shows similar protein distribution across tissues to an independent B4GALT1 Polyclonal Antibody (B).

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产品信息

PA5-52744

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化 (IHC)

1:500-1:1,000

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human B4GALT1. Recombinant protein control fragment (Product #RP-90002).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2638439

产品详细信息

Immunogen sequence: LPQLVGVSTP LQGGSNSAAA IGQSSGELRT GGARPPPPLG ASSQPRPGGD SSPVVDSGPG PASNLTSVPV PHTTALSLPA CPEESPLLVG PMLIEFNMPV DLELVAKQNP NVKM

Highest antigen sequence identity to the following orthologs: Mouse - 71%, Rat - 73%.

靶标信息

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Beta-1,4-galactosyltransferase 1; Beta-1,4-GalTase 1; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; glycoprotein-4-beta-galactosyltransferase 2; Golgi complex; lactose synthase; Lactose synthase A protein; N-acetyllactosamine synthase; Nal synthase; Neolactotriaosylceramide beta-1,4-galactosyltransferase; Processed beta-1; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1

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基因别名: B4GAL-T1; B4GALT1; beta4Gal-T1; CDG2D; GGTB2; GT1; GTB

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UniProt ID: (Human) P15291

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Entrez Gene ID: (Human) 2683

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功能

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity N-acetyllactosamine synthase activity lactose synthase activity cytoskeletal protein binding galactosyltransferase activity protein kinase binding manganese ion binding UDP-galactosyltransferase activity glycosyltransferase

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