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BACE2 Antibody (PA5-29882) in IHC (P)
BACE2 Polyclonal Antibody detects BACE2 protein at cytosol on human breast carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human breast carcinoma. BACE2 Polyclonal Antibody (Product # PA5-29882) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-29882
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 319 and 518 of Human BACE2
偶联物
Unconjugated
形式
Liquid
浓度
0.83 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2547356
产品详细信息
Recommended positive controls: 293T, A431, Jurkat, Raji.
Predicted reactivity: Mouse (88%), Rat (88%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 56 kDa aspartic-like protease; ASP1; Aspartic-like protease 56 kDa; Aspartyl protease 1; be; beta secretase 2; Beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin 1; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase; transmembrane aspartic proteinase Asp1
基因别名: AEPLC; ALP56; ASP1; ASP21; BACE2; BAE2; CDA13; CEAP1; DRAP; UNQ418/PRO852
UniProt ID: (Human) Q9Y5Z0, (Rat) Q6IE75
Entrez Gene ID: (Human) 25825, (Rat) 288227
