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Invitrogen
BAD Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
产品信息
PA5-86037
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within Human Bad aa 1-50
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% Glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2802838
靶标信息
The protein encoded by BAD is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; BCL-X/BCL-2 binding protein; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; BCL2-antagonist of cell death protein; BCL2-associated agonist of cell death; BCL2-binding component 6; BCL2-binding protein; Bcl2-L-8; OTTMUSP00000017561; OTTMUSP00000022400
基因别名: BAD; BBC2; BBC6; BCL2L8
UniProt ID: (Human) Q92934
Entrez Gene ID: (Human) 572
release of cytochrome c from mitochondria
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
glucose catabolic process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
spermatogenesis
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
response to glucose
positive regulation of autophagy
positive regulation of mitochondrial membrane potential
suppression by virus of host apoptotic process
cytokine-mediated signaling pathway
cerebral cortex development
positive regulation of insulin secretion
response to estradiol
response to progesterone
positive regulation of glucokinase activity
response to testosterone
response to oleic acid
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to drug
response to hydrogen peroxide
glucose homeostasis
positive regulation of apoptotic process
response to amino acid
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
type B pancreatic cell proliferation
response to ethanol
positive regulation of B cell differentiation
positive regulation of T cell differentiation
positive regulation of proteolysis
negative regulation of cytolysis
ADP metabolic process
ATP metabolic process
regulation of mitochondrial membrane permeability
pore complex assembly
positive regulation of epithelial cell proliferation
response to glucocorticoid
response to calcium ion
positive regulation of apoptotic process by virus
cellular process regulating host cell cycle in response to virus
cellular response to chromate
cellular response to mechanical stimulus
cellular response to nicotine
cellular response to lipid
cellular response to hypoxia
positive regulation of release of cytochrome c from mitochondria
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
intrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of neuron death
positive regulation of type B pancreatic cell development
positive regulation of intrinsic apoptotic signaling pathway
