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产品信息
PA5-21434
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 195 of BAG5 (Uniprot ID#Q9UL15)
偶联物
Unconjugated
形式
Liquid
浓度
0.68 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153783
产品详细信息
Recommended positive controls: 293T, HeLa, Molt-4, Raji, mouse liver.
Predicted reactivity: Mouse (92%), Rat (91%), Chicken (82%), Chimpanzee (99%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
It has been hypothesizes that the BAG-5 protein will induce the death of nigral neurons through its predicted interaction with hsp70, which will cause increased protein aggregation and cell death by disinhibition of hsp70's anti-apoptotic function. It is believed that BAG-5 will play an important role in the mechanisms of neuronal death. BAG-5 may also be of interest due to its possible role as a modulator of the hsp70/hsp40 chaperone axis or its possible interaction and coordination of localization/ modulation of other BAG containing proteins via BAG-BAG heterodimerization.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BAG family molecular chaperone regulator 5; BAG-5; BAG-family molecular chaperone regulator-5; BAG-family molecular chaperone regulator-5 (BAG-5); Bcl-2-associated athanogene 5; BCL2-associated athanogene 5
基因别名: 1600025G07Rik; 4930405J06Rik; BAG-5; BAG5; KIAA0873
UniProt ID: (Human) Q9UL15, (Mouse) Q8CI32
Entrez Gene ID: (Human) 9529, (Mouse) 70369
protein folding
Golgi organization
negative regulation of neuron projection development
negative regulation of protein ubiquitination
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of ubiquitin-protein transferase activity
negative regulation of ubiquitin-protein transferase activity
negative regulation of protein refolding
neuron death
regulation of inclusion body assembly
regulation of cellular response to heat
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
