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Antibody detects endogenous levels of total Bak.
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Apoptosis regulator BAK; Bcl-2 homologous antagonist/killer; Bcl-2-like protein 7; Bcl2 homologous antagonist/killer; BCL2-antagonist/killer 1; Bcl2-L-7; BCL2-like 7 protein; BCL2-like 7protein; MGC117255; MGC3887; pro-apoptotic protein BAK
基因别名: BAK; BAK-LIKE; BAK1; BCL2L7; CDN1; N-Bak; N-BAK1
UniProt ID: (Human) Q16611, (Mouse) O08734
Entrez Gene ID: (Human) 578, (Mouse) 12018, (Rat) 116502