Invitrogen

BARD1 Polyclonal Antibody

查看其他8个BARD1抗体

产品信息

PA5-75304

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to the N-terminual of Human BARD1.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2719032

产品详细信息

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

靶标信息

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: BARD 1; BARD-1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1

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基因别名: BARD1; ENSMUSG00000060893; ENSMUSG00000073653

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UniProt ID: (Human) Q99728, (Mouse) O70445, (Rat) Q9QZH2

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Entrez Gene ID: (Human) 580, (Mouse) 12021, (Rat) 64557

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RNA binding ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity kinase binding protein homodimerization activity protein heterodimerization activity UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity molecular_function

参与通路

DNA repair cellular response to DNA damage stimulus regulation of phosphorylation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of protein export from nucleus protein K6-linked ubiquitination spermatogenesis DNA double-strand break processing DNA synthesis involved in DNA repair strand displacement tissue homeostasis DNA replication double-strand break repair via nonhomologous end joining cell cycle arrest protein ubiquitination negative regulation of mRNA 3'-end processing positive regulation of protein catabolic process regulation of signal transduction by p53 class mediator