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产品信息
H00000580-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2A11
抗原
BARD1 (NP_000456, 658 a.a. approximately 757 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: RRSRLNREQL LPKLFDGCYF YLWGTFKHHP KDNLIKLVTA GGGQILSRKP KPDSDVTQTI NTVAYHARPD SDQRFCTQYI IYEDLCNYHP ERVRQGKVWK
靶标信息
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
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生物信息学
蛋白别名: BARD 1; BARD-1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1
基因别名: BARD1
UniProt ID: (Human) Q99728
Entrez Gene ID: (Human) 580
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
tissue homeostasis
DNA replication
double-strand break repair via nonhomologous end joining
cellular response to DNA damage stimulus
cell cycle arrest
protein ubiquitination
negative regulation of mRNA 3'-end processing
regulation of phosphorylation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of protein catabolic process
negative regulation of protein export from nucleus
protein K6-linked ubiquitination
regulation of signal transduction by p53 class mediator
