Invitrogen

BBS4 Polyclonal Antibody

查看其他9个BBS4抗体

抗体检测数据 (4)

BBS4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

BBS4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BBS4 Antibody (PA5-58783) in IHC (P)

Immunohistochemical analysis of BBS4 in human Fallopian tube using BBS4 Polyclonal Antibody (Product # PA5-58783) shows moderate membranous and cytoplasmic positivity in glandular cells.

BBS4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

BBS4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

BBS4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

BBS4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

BBS4 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of BBS4 in human Fallopian tube using BBS4 Polyclonal Antibody (Product # PA5-58783) shows moderate membranous and cytoplasmic positivity in glandular cells.

BBS4 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of BBS4 in human prostate using BBS4 Polyclonal Antibody (Product # PA5-58783) shows strong cytoplasmic and membranous positivity in glandular cells.

BBS4 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of BBS4 in human testis using BBS4 Polyclonal Antibody (Product # PA5-58783) shows strong membranous positivity in Leydig cells.

BBS4 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of BBS4 in human liver using BBS4 Polyclonal Antibody (Product # PA5-58783) shows no positivity in hepatocytes as expected.

产品信息

PA5-58783

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

-

免疫组化（石蜡） (IHC (P))

1:200-1:500

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human BBS4. Recombinant protein control fragment (Product #RP-98098).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2638489

产品详细信息

Immunogen sequence: TQFPVSTESQ KPRQKKAPEF PILEKQNWLI HLHYIRKDYE ACKAVIKEQL QETQGLCEYA IYVQALIFRL EGNIQESL

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.

靶标信息

BBS4 contains tetratricopeptide repeats (TPR), similar to O-linked N-acetyglucosamine transferase. Mutations in the gene encoding this protein have been observed in patients with Bardet-Biedl syndrome type 4. BBS4 may play a role in pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Bardet-Biedl syndrome 4 protein; BBSome complex member BBS4

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基因别名: BBS4

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UniProt ID: (Human) Q96RK4

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Entrez Gene ID: (Human) 585

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RNA polymerase II repressing transcription factor binding microtubule motor activity protein binding dynactin binding alpha-tubulin binding beta-tubulin binding

参与通路

microtubule cytoskeleton organization mitotic cytokinesis neuron migration neural tube closure retina homeostasis heart looping negative regulation of systemic arterial blood pressure spermatid development visual perception sensory perception of smell negative regulation of gene expression protein transport dendrite development regulation of lipid metabolic process ventricular system development striatum development hippocampus development cerebral cortex development adult behavior negative regulation of actin filament polymerization melanosome transport regulation of cytokinesis protein localization to organelle negative regulation of GTPase activity microtubule anchoring at centrosome nonmotile primary cilium assembly social behavior photoreceptor cell outer segment organization negative regulation of appetite by leptin-mediated signaling pathway positive regulation of multicellular organism growth cilium assembly fat cell differentiation photoreceptor cell maintenance positive regulation of cilium assembly retinal rod cell development intracellular transport brain morphogenesis sensory processing centrosome organization maintenance of protein location in nucleus regulation of stress fiber assembly cilium morphogenesis regulation of cilium beat frequency involved in ciliary motility face development fat pad development protein localization to cilium protein localization to centrosome regulation of nonmotile primary cilium assembly protein localization to photoreceptor outer segment