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BBS5 Antibody (PA5-104312) in IHC (P)
Immunohistochemistry analysis of BBS5 in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with BBS5 polyclonal antibody (Product # PA5-104312) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-104312
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human BBS5(Accession Q8N3I7), corresponding to amino acid residues T280-G330.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2853622
产品详细信息
Antibody detects endogenous levels of total BBS5.
靶标信息
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bardet-Biedl syndrome 5 homolog; Bardet-Biedl syndrome 5 protein; Bardet-Biedl syndrome 5 protein homolog; BBSome complex member BBS5; novel DUF1448 protein
基因别名: 1700049I01Rik; 2700023J09Rik; BBS5
UniProt ID: (Human) Q8N3I7, (Mouse) Q9CZQ9
Entrez Gene ID: (Human) 129880, (Mouse) 72569, (Rat) 362142
