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产品信息
IHC-00636
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 264 and 314 of human BRCA2 and CDKN1A interacting protein.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.^M
^M
Based on 100% sequence identity, this antibody is predicted to react with Gorilla, Green anole and White-tufted-ear marmoset
靶标信息
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
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生物信息学
蛋白别名: BCCIPalpha; BCCIPbeta; BRCA2 and CDKN1A-interacting protein; BRCA2 and Cip1/p21 interacting protein; cdk inhibitor p21 binding protein; P21- and CDK-associated protein 1; Protein TOK-1; TOK-1alpha; TOK-1beta
基因别名: BCCIP; TOK-1; TOK1
UniProt ID: (Human) Q9P287
Entrez Gene ID: (Human) 56647
