Invitrogen

BCOR Polyclonal Antibody

BCOR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BCOR Antibody (PA5-49904) in IHC (P)

Immunohistochemical analysis of BCOR in paraffin-embedded Human breast carcinoma tissue using BCOR Polyclonal Antibody (Product # PA5-49904).

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产品信息

PA5-49904

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化（石蜡） (IHC (P))

1:50-1:100

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from internal of human BCOR.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2635357

产品详细信息

The antibody detects endogenous levels of total BCOR protein.

靶标信息

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).

仅用于科研。不用于诊断过程。未经明确授权不得转售。