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产品信息
PA5-59508
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2638552
产品详细信息
Immunogen sequence: YRQSRVTRSG SLKGPDDPRG LLSPRLARRG VSSPVETRTS SEPVAKESTE ASKEPSPTKT PTISPVITAP PSSPVLDTSD IRKE
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
靶标信息
BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Bic-D 1; bicaudal D homolog 1; cytoskeleton-like bicaudal D protein homolog 1; Protein bicaudal D homolog 1
基因别名: BICD; BICD1
UniProt ID: (Human) Q96G01
Entrez Gene ID: (Human) 636
RNA processing
intracellular mRNA localization
anatomical structure morphogenesis
viral process
protein localization to organelle
stress granule assembly
positive regulation of receptor-mediated endocytosis
minus-end-directed organelle transport along microtubule
microtubule anchoring at microtubule organizing center
negative regulation of phospholipase C activity
regulation of proteinase activated receptor activity
negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
