Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 3
BMP-7 Antibody (500-P198-1MG) in WB
Western Blot: To detect Human BMP-7 by Western Blot analysis BMP-7 Polyclonal Antibody (Product # 500-P198-1MG) can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human BMP-7 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
产品信息
500-P198-1MG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
CHO cells-derived Recombinant Human BMP-7
偶联物
形式
Lyophilized
浓度
0.1-1.0 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
RRID
AB_2929775
产品详细信息
AA Sequence of recombinant protein: MANVAENSSS DQRQACKKHE LYVSFRDLGW QDWIIAPEGY AAYYCEGECA FPLNSYMNAT NHAIVQTLVH FINPETVPKP CCAPTQLNAI SVLYFDDSSN VILKKYRNMV VRACGCH.
Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human BMP-7. Anti-Human BMP-7-specific antibody was purified by affinity chromatography employing an immobilized Human BMP-7 matrix.
Sandwich ELISA: To detect Human BMP-7 by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.5-2.0 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human BMP-7 (500-P198Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human BMP-7.
Western Blot: To detect Human BMP-7 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human BMP-7 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
靶标信息
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, BMP7 has a proposed role in early development. In addition, the fact that BMP7 is closely related to BMP5 and BMP6 has lead to speculation of possible bone inductive activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BMP; BMP-7; Bone morphogenetic protein; Bone morphogenetic protein 7; OP-1; Osteogenic protein 1; RP11-560A15.5
基因别名: BMP7; OP-1; OP1
UniProt ID: (Human) P18075
Entrez Gene ID: (Human) 655
skeletal system development
ossification
metanephros development
ureteric bud development
mesoderm formation
mesonephros development
epithelial to mesenchymal transition
axon guidance
embryonic pattern specification
negative regulation of striated muscle cell apoptotic process
positive regulation of peptidyl-threonine phosphorylation
positive regulation of pathway-restricted SMAD protein phosphorylation
dendrite development
embryonic limb morphogenesis
positive regulation of bone mineralization
BMP signaling pathway
epithelial cell differentiation
negative regulation of NF-kappaB transcription factor activity
response to estradiol
response to vitamin D
positive regulation of heterotypic cell-cell adhesion
protein localization to nucleus
growth
negative regulation of phosphorylation
negative regulation of NF-kappaB import into nucleus
odontogenesis of dentin-containing tooth
regulation of apoptotic process
positive regulation of apoptotic process
steroid hormone mediated signaling pathway
negative regulation of MAP kinase activity
response to peptide hormone
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
negative regulation of Notch signaling pathway
negative regulation of cell cycle
negative regulation of mitotic nuclear division
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic camera-type eye morphogenesis
branching morphogenesis of an epithelial tube
mesenchymal cell differentiation
neuron projection morphogenesis
cartilage development
embryonic skeletal joint morphogenesis
regulation of pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
branching involved in salivary gland morphogenesis
mesenchyme development
negative regulation of cell death
negative regulation of prostatic bud formation
regulation of branching involved in prostate gland morphogenesis
monocyte aggregation
cellular response to hypoxia
cellular response to BMP stimulus
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
negative regulation of glomerular mesangial cell proliferation
metanephric mesenchyme morphogenesis
nephrogenic mesenchyme morphogenesis
metanephric mesenchymal cell proliferation involved in metanephros development
positive regulation of dendrite development
positive regulation of hyaluranon cable assembly
regulation of removal of superoxide radicals
