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产品信息
H00000658-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2F3
抗原
BMPR1B (AAH47773, 14 a.a. approximately 502 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: KKEDGESTAP TPRPKVLRCK CHHHCPEDSV NNICSTDGYC FTMIEEDDSG LPVVTSGCLG LEGSDFQCRD TPIPHQRRSI ECCTERNECN KDLHPTLPPL KNRDFVDGPI HHRALLISVT VCSLLLVLII LFCYFRYKRQ ETRPRYSIGL EQDETYIPPG ESLRDLIEQS QSSGSGSGLP LLVQRTIAKQ IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDAKSMLK LAYSSVSGLC HLHTEIFSTQ GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL DESLNRNHFQ SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI VCIKKLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTFAK MSESQDIKL
靶标信息
BMPR1B (also known as ALK6, CDw293) is a member of the transmembrane serine/threonine kinase that is the member of the bone morphogenetic protein (BMP) receptor, which is closely related to the activin receptors, ACVR1 and ACVR2. BMPR1B is mainly involved in the endochondral bone formation and embryogenesis. BMPR1B expressed in normal and cancerous prostate tissues and used in the endocrine therapy that given to the prostate cancer patients. BMPR1B receptor trafficking also play a significant role in FOP pathogenesis and used in human T-cell differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activin receptor-like kinase 6; BMP type-1B receptor; BMPR-1B; bone morphogenetic protein receptor type IB; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293; serine/threonine receptor kinase
基因别名: ALK-6; ALK6; AMDD; BDA1D; BDA2; BMPR1B; CDw293
UniProt ID: (Human) O00238
Entrez Gene ID: (Human) 658
glycoprotein binding
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
SMAD binding
metal ion binding
serine/threonine protein kinase receptor
skeletal system development
cartilage condensation
ovarian cumulus expansion
eye development
chondrocyte development
protein phosphorylation
inflammatory response
dorsal/ventral pattern formation
signal transduction by protein phosphorylation
proteoglycan biosynthetic process
positive regulation of bone mineralization
BMP signaling pathway
retinal ganglion cell axon guidance
positive regulation of chondrocyte differentiation
limb morphogenesis
ovulation cycle
positive regulation of cell differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
retina development in camera-type eye
endochondral bone morphogenesis
positive regulation of cartilage development
cellular response to BMP stimulus
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of chondrocyte proliferation
