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Invitrogen
CD44std Monoclonal Antibody (SFF-304), FITC, eBioscience™
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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CD44std Antibody (BMS150FI) in Flow
Staining of human peripheral blood mononuclear cells with CD45 Pacific Blue, CD41 APC and CD44std FITC. As expected based on known relative expression patterns, CD44std clone SFF-304 stains lymphocytes (pink), monocytes (orange), granulocytes (blue) and a small subset of CD45 negative cells (green).
产品信息
BMS150FI
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, lambda
分类
Monoclonal
类型
Antibody
克隆号
SFF-304
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
10 µL/Test
纯化类型
Affinity chromatography
保存液
TBS, pH 7.2-7.4, with 1% BSA
内含物
0.02% sodium azide
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10596828
产品详细信息
Description: BMS150 specifically recognizes human standard CD44, but cannot be used to distinguish between splice variants (exon v3-v10).
CD44 is a cell membrane associated, polymorphic glycoprotein with apparent molecular weights ranging from 85 kDa to 250 kDa. CD44 isoforms participate in a wide variety of cell-cell or cell-matrix interactions including lymphocyte homing, establishment of B and T cell immune responses, tumor metastases formation and inflammation.
Three isoform categories of the CD44 molecule have been identified:
1) an 80-90 kDa isoform, the so-called standard form named CD44std, which is widely distributed on several hematopoietic and nonhemato-poietic cells including all subsets of leukocytes, monocytes, erythrocytes, many types of epithelium, mesenchymal elements like fibroblasts, smooth muscle cells and glial cells of the central nervous system,
2) a medium size category of 110-160 kDa which is weakly expressed on epithelial cells and highly expressed in some carcinomas and
3) a category which includes very large isoforms of 250 kDa covalently modified by the addition of chondroitin sulfate.
These bigger isoforms of CD44 arise by alternative splicing of one or more "variant" exons (v2-v10) into the extracellular part of the 90 kDa constant form molecule. Compared to the standard CD44, all larger isoforms are expressed in a much more restricted fashion, only in a few normal tissues or on the surface of certain tumor cells. Some splice variants of
靶标信息
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD44; CD44 antigen; CD44 molecule; CDw44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; PGP I; PGP-1; PGP-I; PGPI; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44; soluble CD44
基因别名: CD44; CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1
UniProt ID: (Human) Q16064
Entrez Gene ID: (Human) 960
cell-matrix adhesion
single organismal cell-cell adhesion
extracellular matrix disassembly
extracellular matrix organization
hyaluronan catabolic process
positive regulation of peptidyl-serine phosphorylation
positive regulation of heterotypic cell-cell adhesion
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
cellular response to fibroblast growth factor stimulus
positive regulation of peptidyl-tyrosine phosphorylation
leukocyte migration
cartilage development
interferon-gamma-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
monocyte aggregation
positive regulation of monocyte aggregation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
