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产品信息
PA5-21656
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 9 and 328 (Q9NXR7) of BRE
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11155399
产品详细信息
Recommended positive controls: HeLa, 293T, A431, C8D30, rat testis.
Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (85%), Xenopus laevis (91%), Chicken (97%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brain and reproductive organ-expressed protein; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; BRCA1/BRCA2-containing complex, subunit 4; bre; bre {ECO:0000312|RGD:735111}; BRISC and BRCA1-A complex member 2
基因别名: 6030405P19Rik; AI429776; B830038C02Rik; BABAM2; BRCC4; BRCC45; BRE
UniProt ID: (Human) Q9NXR7, (Mouse) Q8K3W0, (Rat) Q6P7Q1
Entrez Gene ID: (Human) 9577, (Mouse) 107976, (Rat) 362704
DNA repair
double-strand break repair
apoptotic process
cellular response to DNA damage stimulus
response to ionizing radiation
chromatin modification
G2 DNA damage checkpoint
positive regulation of DNA repair
double-strand break repair via nonhomologous end joining
mitotic nuclear division
signal transduction
covalent chromatin modification
cell division
protein K63-linked deubiquitination
