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产品信息
PA5-101216
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human BRSK1(Accession Q8TDC3), corresponding to amino acid residues Y352-V402.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850657
产品详细信息
Antibody detects endogenous levels of total BRSK1.
靶标信息
BRSK1 (SAD1) is a serine/threonine kinase, and is a UV-induced DNA damage checkpoint kinase. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BR serine/threonine-protein kinase 1; Brain-selective kinase 1; Brain-specific serine/threonine-protein kinase 1; protein kinase SAD1A; SAD1 homolog; SAD1 kinase; SAD1A; SadB kinase short isoform; serine/threonine kinase SAD-B; serine/threonine kinase SADB; Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog 1
基因别名: BRSK1; Gm1100; hSAD1; KIAA1811; SAD-B; SAD1; SADB
UniProt ID: (Human) Q8TDC3, (Mouse) Q5RJI5
Entrez Gene ID: (Human) 84446, (Mouse) 381979
magnesium ion binding
protein serine/threonine kinase activity
ATP binding
protein kinase binding
gamma-tubulin binding
tau-protein kinase activity
nucleotide binding
protein kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
protein phosphorylation
cellular response to DNA damage stimulus
neurotransmitter secretion
axonogenesis
response to UV
response to ionizing radiation
establishment of cell polarity
neuron differentiation
G2 DNA damage checkpoint
intracellular signal transduction
centrosome duplication
G2/M transition of mitotic cell cycle
cell cycle
nervous system development
phosphorylation
peptidyl-serine phosphorylation
neuron projection morphogenesis
