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Bcl-10 Antibody (PA1-4129) in WB
Western blot detection of Bcl10 from transfected 293 cells using Product # PA1-4129.
产品信息
PA1-4129
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues E(220) M F L P L R S R T V S R Q(233) C of Bcl10.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2063988
产品详细信息
PA1-4129 detects Bcl10 in human samples.
PA1-4129 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~26 kDa protein representing Bcl10 in transfected 293 cells.
The PA1-4129 immunogen is a synthetic peptide corresponding to residues E(220) M F L P L R S R T V S R Q(233) C of Bcl10.
靶标信息
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; hCLAP; Mamm; Mammalian CARD-containing adapter molecule E10; mE10; OTTHUMP00000011647; OTTHUMP00000036080; RP11-234D19.2
基因别名: BCL10; c-E10; CARMEN; CIPER; CLAP; IMD37; mE10
UniProt ID: (Human) O95999
Entrez Gene ID: (Human) 8915
protease binding
transcription coactivator activity
protein binding
protein C-terminus binding
transcription factor binding
kinase activator activity
enzyme binding
kinase binding
protein kinase binding
ubiquitin protein ligase binding
identical protein binding
ubiquitin binding
protein kinase B binding
protein self-association
NF-kappaB binding
B cell apoptotic process
neural tube closure
stimulatory C-type lectin receptor signaling pathway
toll-like receptor signaling pathway
response to molecule of bacterial origin
adaptive immune response
negative regulation of mature B cell apoptotic process
cellular defense response
I-kappaB kinase/NF-kappaB signaling
cell death
response to fungus
immunoglobulin mediated immune response
positive regulation of protein ubiquitination
response to food
positive regulation of mast cell cytokine production
Fc-epsilon receptor signaling pathway
lymphotoxin A biosynthetic process
interleukin-6 biosynthetic process
positive regulation of phosphorylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
innate immune response
positive regulation of interleukin-8 biosynthetic process
positive regulation of transcription, DNA-templated
T cell receptor signaling pathway
regulation of T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
protein homooligomerization
protein heterooligomerization
T cell apoptotic process
cellular response to mechanical stimulus
positive regulation of extrinsic apoptotic signaling pathway
