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Invitrogen

Beclin 1 Polyclonal Antibody

3个已发表图片

6 篇参考文献

查看其他37个Beclin 1抗体

说明书

实验方案

技术支持

货号 PA1-16857

CNY 5,929.00

100 µL

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批量或定制请求

说明书

实验方案

技术支持

抗体检测数据 (4)
已发表图片 (3)

Application

Beclin 1 Antibody in Immunohistochemistry (Frozen) (IHC (F))

图: 1 / 7

Beclin 1 Antibody (PA1-16857) in IHC (F)

Immunohistochemical analysis of Beclin 1 in Pheochromocytes of the Adrenal Medulla. Samples were incubated in Beclin 1 polyclonal antibody (Product # PA1-16857). Antibody shown in red. Magnification 40X.

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产品信息

PA1-16857

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看6篇已发表文章 6篇已发表文章

免疫组化（石蜡） (IHC (P))

1:400

免疫组化（冰冻） (IHC (F))

1:400

免疫细胞化学 (ICC/IF)

1:50-1:200

流式细胞分析 (Flow)

2-10 µg/mL

免疫沉淀 (IP)

1:80

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide to human Beclin 1, containing residues within 1-100.

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偶联物

Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_568459

产品详细信息

The target sequence has 88% sequence homology with rat.

Suggested positive control: antigen standard for BECN1 (transient overexpression lysate).

靶标信息

Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Computational and Experimental Approaches Exploring the Role of Hesperetin in Improving Autophagy in Rat Diabetic Retinopathy.

Biomedicines

Alshaman R,Kolieb E,El-Sayed RM,Gouda SG,Alattar A,Zaitone SA,Abdelmaogood AKK,Elabbasy LM,Eltrawy AH,Sayd FY,Mokhtar HI,Wafa EGAE,Ahmed ES,Liang D,Ali DA

Published figure using Beclin 1 polyclonal antibody (Product # PA1-16857) in Western Blot

Fri Mar 01 00:00:00 UTC 2024

Curcumin affects autophagy of prolactinoma cells by upregulating miR-206 to exert antitumor effects.

Journal of biochemical and molecular toxicology

Duan JF,Zhang QJ,Zhu J,Lu JH

Published figure using Beclin 1 polyclonal antibody (Product # PA1-16857) in Western Blot

Sat Jun 01 00:00:00 UTC 2024

Elucidating the molecular mechanisms underlying the induction of autophagy by antidepressant-like substances in C57BL/6J mouse testis model upon LPS challenge.

Cell communication and signaling : CCS

Sołek P,Czechowska E,Sowa-Kućma M,Stachowicz K,Kaczka P,Tabęcka-Łonczyńska A

Published figure using Beclin 1 polyclonal antibody (Product # PA1-16857) in Western Blot

Thu Sep 21 00:00:00 UTC 2023

Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy.

Journal of translational medicine

Taib N,Merhi M,Inchakalody V,Mestiri S,Hydrose S,Makni-Maalej K,Raza A,Sahir F,Azizi F,Nizamuddin PB,Fernandes Q,Yoosuf ZSKM,Almoghrabi S,Al-Zaidan L,Shablak A,Uddin S,Maccalli C,Al Homsi MU,Dermime S

PA1-16857 was used in Western Blot to compare the effect of Decitabine in primary 1076 Col and metastatic 1872 Col cell lines isolated and generated from patients' tumor tissues.

Fri Mar 31 00:00:00 UTC 2023

Intracardiac administration of ephrinA1-Fc preserves mitochondrial bioenergetics during acute ischemia/reperfusion injury.

Life sciences

Torres MJ,McLaughlin KL,Renegar RH,Valsaraj S,Whitehurst KS,Sharaf OM,Sharma UM,Horton JL,Sarathy B,Parks JC,Brault JJ,Fisher-Wellman KH,Neufer PD,Virag JAI

PA1-16857 was used in Western Blotting to suggest that intracardiac injection of EphrinA1-Fc protects cardiac function by preserving cardiomyocyte structure and mitochondrial bioenergetics, thus emerging as a potential therapeutic strategy in I/R injury.

Sun Dec 15 00:00:00 UTC 2019

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer.

Cell reports

Bacci M,Lorito N,Ippolito L,Ramazzotti M,Luti S,Romagnoli S,Parri M,Bianchini F,Cappellesso F,Virga F,Gao Q,Simões BM,Marangoni E,Martin LA,Comito G,Ferracin M,Giannoni E,Mazzone M,Chiarugi P,Morandi A

PA1-16857 was used in Western Blotting to provide insight into the metabolic deregulation of endocrine therapy resistant (ETR) cells, and discover molecules that may prove useful in identifying a signature for breast cancer patients with an increased risk of ETR.

Tue Jul 02 00:00:00 UTC 2019

生物信息学

蛋白别名: APG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e

基因别名: 4921513J16Rik; 5430417M23Rik; ATG6; beclin1; BECN1; GT197; VPS30

UniProt ID: (Human) Q14457, (Rat) Q91XJ1, (Mouse) O88597

Entrez Gene ID: (Human) 8678, (Rat) 114558, (Mouse) 56208

功能

protein binding ubiquitin protein ligase binding phosphatidylinositol 3-kinase binding molecular_function protease inhibitor

参与通路

autophagosome assembly cytokinesis response to hypoxia autophagy apoptotic process cellular defense response cellular response to nitrogen starvation lysosome organization mitotic metaphase plate congression negative regulation of cell proliferation positive regulation of autophagy positive regulation of phosphatidylinositol 3-kinase signaling macroautophagy positive regulation of macroautophagy CVT pathway regulation of cytokinesis receptor catabolic process response to vitamin E cellular response to glucose starvation response to drug negative regulation of apoptotic process engulfment of apoptotic cell nucleophagy late endosome to vacuole transport neuron development beta-amyloid metabolic process regulation of catalytic activity defense response to virus negative regulation of cell death cellular response to aluminum ion cellular response to epidermal growth factor stimulus mitophagy in response to mitochondrial depolarization positive regulation of attachment of mitotic spindle microtubules to kinetochore positive regulation of mitophagy negative regulation of reactive oxygen species metabolic process mitophagy response to other organism angiogenesis cell cycle cell division

Beclin 1 Polyclonal Antibody

Beclin 1 Antibody (PA1-16857) in IHC (F)

产品信息

PA1-16857

免疫印迹 (WB)

免疫组化（石蜡） (IHC (P))

免疫组化（冰冻） (IHC (F))

免疫细胞化学 (ICC/IF)

流式细胞分析 (Flow)

免疫沉淀 (IP)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

Beclin 1 Polyclonal Antibody

Beclin 1 Antibody (PA1-16857) in IHC (F)

产品信息

PA1-16857

免疫印迹 (WB)

免疫组化（石蜡） (IHC (P))

免疫组化（冰冻） (IHC (F))

免疫细胞化学 (ICC/IF)

流式细胞分析 (Flow)

免疫沉淀 (IP)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#A2A2A2;}

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

RRID