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Beta 1 Na+/K+ ATPase (extracellular) Antibody (ANP-014-200UL) in IHC (F)
Expression of Beta 1 Na+/K+ATPase in rat cerebellum. Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-Beta 1 Na+/K+ATPase (extracellular) Antibody (#ANP-014), (1:200), followed by goat Anti-rabbit-AlexaFluor-488. A. Beta 1 Na+/K+ATPase immunoreactivity (green) appears in structures surrounding Purkinje cell soma (down pointing arrows) and in cone-shaped structures at the P... View More
产品信息
ANP-014-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide CKAYGENIGYSEKDR, corresponding to amino acid residues 277-291 of mouse ATP1B1, Extracellular, C-terminus
偶联物
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adenosinetriphosphatase; ATPase, Na+/K+ transporting, beta 1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; MGC1798; Na+/K+ ATPase Beta; Na, K-ATPase beta-1 polypeptide; Na,K-ATPase beta 1 subunit; OTTHUMP00000032537; OTTHUMP00000032538; Sodium Potassium ATPase; sodium pump subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); sodium/potassium ATPase beta subunit; sodium/potassium-dependent ATPase beta-1 subunit; Sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase beta-1 chain; Sodium/potassium-transporting ATPase subunit beta-1
基因别名: ATP1B; ATP1B1; Atp4b; Atpb; Atpb-1; ATPBS; NKbeta1
UniProt ID: (Human) P05026, (Rat) P07340, (Mouse) P14094
Entrez Gene ID: (Human) 481, (Rat) 25650, (Mouse) 11931
response to hypoxia
positive regulation of defense response to virus by host
cellular calcium ion homeostasis
cellular sodium ion homeostasis
cell adhesion
potassium ion import
establishment or maintenance of transmembrane electrochemical gradient
regulation of gene expression
regulation of cardiac muscle contraction by calcium ion signaling
cellular potassium ion homeostasis
positive regulation of ATPase activity
ion transmembrane transport
sodium ion export from cell
protein transport into plasma membrane raft
ATP metabolic process
protein stabilization
leukocyte migration
relaxation of cardiac muscle
cardiac muscle contraction
protein localization to plasma membrane
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
ATP hydrolysis coupled transmembrane transport
mitophagy in response to mitochondrial depolarization
xenophagy
positive regulation of potassium ion transmembrane transporter activity
positive regulation of sodium ion export from cell
positive regulation of calcium:sodium antiporter activity
positive regulation of potassium ion import
regulation of cardiac conduction
potassium ion import across plasma membrane
blastocyst development
potassium ion transport
sodium ion transport
metal ion transport
regulation of calcium ion transmembrane transport
transport
ion transport
