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产品信息
PA5-90693
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 100-198 of human Bim (NP_6195271)
偶联物
形式
Liquid
浓度
3.35 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806180
产品详细信息
Positive Samples: Raji, Jurkat, 293T, HeLa, mouse spleen; Cellular Location: Endomembrane system, Mitochondrion, Peripheral membrane protein
Immunogen sequence: DTDRSPAPMS CDKSTQTPSP PCQAFNHYLS AMASMRQAEP ADMRPEIWIA QELRRIGDEF NAYYARRVFL NNYQAAEDHP RMVILRLLRY IVRLVWRMH
靶标信息
BIM belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; Bcl-2 like 11; Bcl-2 related apoptotic gene product BimL; Bcl-2-like protein 11; bcl-2-related ovarian death agonist; Bcl-2-related ovarian death protein; Bcl2 interacting mediator of cell death; Bcl2-interacting mediator of cell death; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); Bim EL; Bim-A; BIM-alpha6; BIM-beta6; BIM-beta7; OTTHUMP00000197013; OTTHUMP00000204247
基因别名: 1500006F24Rik; BAM; bcl2-L-11; BCL2L11; BIM; BimL; BOD
UniProt ID: (Human) O43521, (Mouse) O54918, (Rat) O88498
Entrez Gene ID: (Human) 10018, (Mouse) 12125, (Rat) 64547
in utero embryonic development
leukocyte homeostasis
B cell homeostasis
B cell apoptotic process
kidney development
lymphocyte homeostasis
myeloid cell homeostasis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell-matrix adhesion
spermatogenesis
male gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
post-embryonic development
positive regulation of cell death
mammary gland development
positive regulation of protein homooligomerization
response to endoplasmic reticulum stress
tube formation
odontogenesis of dentin-containing tooth
regulation of apoptotic process
T cell homeostasis
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of neuron apoptotic process
ear development
positive regulation of cell cycle
regulation of organ growth
developmental pigmentation
regulation of developmental pigmentation
spleen development
thymus development
post-embryonic organ morphogenesis
positive regulation of apoptotic process by virus
cellular process regulating host cell cycle in response to virus
thymocyte apoptotic process
positive regulation of release of cytochrome c from mitochondria
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of mitochondrial membrane permeability involved in apoptotic process
apoptotic process involved in embryonic digit morphogenesis
positive regulation of fibroblast apoptotic process
positive regulation of intrinsic apoptotic signaling pathway
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
meiosis I
brain development
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of IRE1-mediated unfolded protein response
