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Bombesin Receptor 3 Antibody (PA5-32677) in IHC (P)
Immunohistochemistry analysis of Bombesin Receptor 3 in human brain. Samples were incubated with Bombesin Receptor 3 polyclonal antibody (Product # PA5-32677). Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
产品信息
PA5-32677
产品规格
种属反应
Bovine,
Dog,
Horse,
Guinea pig,
Hamster,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human BRS3.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550140
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Mouse, Rat, Bovine, Dog, Hamster, Panda, Horse, Guinea pig (100%); Monkey, Marmoset, Sheep, Elephant, Rabbit (95%); Bat (85%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
靶标信息
BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bombesin like receptor 3; Bombesin receptor subtype-3; bombesin receptor subtype-3-like protein; bombesin-like receptor 3; BRS 3; BRS-3; G-protein coupled receptor; RP1-196E23.3
基因别名: BB3; BB3R; BRS-3; BRS3
UniProt ID: (Human) P32247, (Mouse) O54798, (Rat) Q8K418, (Guinea pig) P35371
