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Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Mouse, Rat, Bovine, Dog, Hamster, Panda, Horse, Guinea pig (100%); Monkey, Marmoset, Sheep, Elephant, Rabbit (95%); Bat (85%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: bombesin like receptor 3; Bombesin receptor subtype-3; bombesin receptor subtype-3-like protein; bombesin-like receptor 3; BRS 3; BRS-3; G-protein coupled receptor; RP1-196E23.3
基因别名: BB3; BB3R; BRS-3; BRS3
UniProt ID: (Human) P32247, (Mouse) O54798, (Rat) Q8K418, (Guinea pig) P35371
Entrez Gene ID: (Human) 680, (Horse) 100054718, (Bovine) 539011, (Dog) 613002, (Chinese hamster) 100763382, (Mouse) 12209, (Rat) 260319, (Guinea pig) 100135488
分子生物学功能:
transmembrane signal receptor