Invitrogen

C-Peptide Monoclonal Antibody (C-PEP-01), Biotin

查看其他10个C-Peptide抗体

产品信息

MA1-10317

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

Assay-dependent

-

免疫细胞化学 (ICC/IF)

Assay-dependent

-

酶联免疫吸附实验 (ELISA)

Assay-dependent

-

放射免疫测定 (RIA)

Assay-dependent

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

C-PEP-01

抗原

Human C-peptide conjugated to bovine serum albumin.

偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

1 mg/mL

纯化类型

Size-exclusion chromatography

保存液

PBS, pH 7.4

内含物

15mM sodium azide

保存条件

4° C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_11152740

产品详细信息

This antibody reacts specifically with C-peptide, a part of the proinsulin molecule. Proinsulin consists of three parts: C-peptide and two long strands of amino acids (alpha and beta chains; later become linked together to form the insulin molecule). No cross-reactivity with insulin or other peptide hormones or proteins was observed.

靶标信息

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Cpeptide; Insulin; preproinsulin; proinsulin

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基因别名: IDDM; IDDM1; IDDM2; ILPR; INS; IRDN; MODY10

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UniProt ID: (Human) P01308

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Entrez Gene ID: (Human) 3630

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protease binding insulin receptor binding insulin-like growth factor receptor binding hormone activity protein binding identical protein binding growth factor

参与通路

MAPK cascade negative regulation of acute inflammatory response glucose metabolic process regulation of transcription, DNA-templated regulation of cellular amino acid metabolic process ER to Golgi vesicle-mediated transport acute-phase response G-protein coupled receptor signaling pathway cell-cell signaling positive regulation of cell proliferation insulin receptor signaling pathway positive regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling glucose transport regulation of transmembrane transporter activity positive regulation of cell growth positive regulation of cell migration positive regulation of protein autophosphorylation activation of protein kinase B activity positive regulation of cellular protein metabolic process negative regulation of protein oligomerization regulation of protein localization negative regulation of NAD(P)H oxidase activity wound healing negative regulation of protein catabolic process glucose homeostasis positive regulation of MAPK cascade cellular protein metabolic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation negative regulation of gluconeogenesis positive regulation of glycogen biosynthetic process positive regulation of DNA replication negative regulation of glycogen catabolic process positive regulation of glycolytic process positive regulation of mitotic nuclear division negative regulation of proteolysis negative regulation of vasodilation positive regulation of vasodilation negative regulation of fatty acid metabolic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway alpha-beta T cell activation positive regulation of lipid biosynthetic process regulation of protein secretion negative regulation of protein secretion positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation negative regulation of lipid catabolic process positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity positive regulation of protein kinase B signaling fatty acid homeostasis negative regulation of respiratory burst involved in inflammatory response positive regulation of respiratory burst positive regulation of peptide hormone secretion positive regulation of brown fat cell differentiation positive regulation of protein localization to nucleus negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of feeding behavior