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C5aR2 (extracellular) Antibody (AAR-034-200UL) in IHC (F)
Expression of C5aR2 in rat hippocampus. Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-C5aR2 (extracellular) Antibody (#AAR-034), (1: 300), followed by goat Anti-rabbit-AlexaFluor-488. A. Staining in the hippocampal CA1 region, showed C5aR2 immunoreactivity (green) in glial profiles (arrows). B. Pre-incubation of the Antibody with C5aR2 (extracellular) Blocking Peptide (... View More
产品信息
AAR-034-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)RRLLQEHYPPRLV(S)G, corresponding to amino acid residues 179-193 of mouse C5aR2, Extracellular, 2nd loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
C5AR2 is an orphan member that belongs to anaphylatoxin receptor family. It is a seven transmembrane G-protein-coupled receptor consisting of an N-terminal N-glycosylation site, several conserved cysteines and several potential C-terminal phosphorylation sites. It binds to C5a and C5a-des-Arg and serves as a highly regulated scavenger receptor with a negative modulatory influence on C5aR-mediated inflammation. Northern Blot analysis suggests it is co- expressed along with C5aR in different tissues and cells including neutrophils/macrophages, mast cells, dendritic cells, brain, lung, heart, kidney, liver, ovary and testis.
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生物信息学
蛋白别名: C5a anaphylatoxin chemotactic receptor 2; C5a anaphylatoxin chemotactic receptor C5L2; C5A receptor beta; complement 5A receptor beta; Complement component 5a receptor 2; G protein-coupled receptor 77; G-protein coupled receptor 77
基因别名: C5ar2; C5L2; E030029A11Rik; Gpr77
UniProt ID: (Rat) Q695P6, (Mouse) Q8BW93
Entrez Gene ID: (Rat) 445269, (Mouse) 319430
chemotaxis
inflammatory response
G-protein coupled receptor signaling pathway
negative regulation of tumor necrosis factor production
positive regulation of epithelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
negative regulation of neutrophil chemotaxis
negative regulation of interleukin-6 secretion
regulation of interleukin-8 secretion
signal transduction
