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产品信息
PA5-60313
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2639207
产品详细信息
Immunogen sequence: EPGGKVGLLN HRPVAMDAGD SADQSGERKD KESPRAGPTE PMDTSEATVC HSDLERTPPL LPGRPARDRG PESRPTELSL E
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 68%.
靶标信息
Calcineurin binding protein (Cabin-1) and the corresponding rat homolog, designated Cain, are widely expressed nuclear phosphoproteins that regulate the serine/threonine phosphotase activity of calcineurin and influence T cell signaling and apoptosis. Calcineurin is required for the transcriptional activation of cytokines and the activation of various transcription factors, including NFAT, NFκB and AP-1, involved in T cell receptor (TCR)-mediated signaling. The regulation of calcineurin depends on the changes in intracellular calcium concentrations and the activity of protein kinase C. TCR activation results in PKC inducing the hyperphosphorylation of Cabin-1, which facilitates the high affinity binding of Cabin-1 to calcineurin. This complex formation, in turn, inhibits calcineurin activity and attenuates TCR-mediated signaling. Cabin-1 also associates directly with MEF-2 proteins, a family of transcription factors that regulate apoptosis signaling in T cells. This association between Cabin-1 and MEF-2 leads to the inhibition of MEF-2-mediated gene transcription and the inhibition of apoptosis.
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生物信息学
蛋白别名: CAIN; calcineurin binding protein cabin 1; Calcineurin inhibitor; Calcineurin-binding protein cabin-1
基因别名: CABIN1; CAIN; KB-318B8.7; KIAA0330; PPP3IN
UniProt ID: (Human) Q9Y6J0
Entrez Gene ID: (Human) 23523
