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CADM1 Antibody (PA5-102512) in IHC (P)
Immunohistochemistry analysis of CADM1 in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with CADM1 polyclonal antibody (Product # PA5-102512) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-102512
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CADM1(Accession Q9BY67), corresponding to amino acid residues S105-T155.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851914
产品详细信息
Antibody detects endogenous levels of total CADM1.
靶标信息
Mediates homophilic cell-cell adhesion in a Ca (2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca (2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CADM1; Cell adhesion molecule 1; cell adhesion molecule 1 transcript variant 8abc; IgSF4; Immunoglobulin superfamily member 4; immunoglobulin superfamily member 4A; immunoglobulin superfamily, member 4; immunoglobulin superfamily, member 4A; immunoglobulin superfamily, member 4D variant 1; immunoglobulin superfamily, member 4D variant 2; immunosuperfamily protein Bl2; NECL-2; nectin-like 2; Nectin-like protein 2; secretory isoform of TSLC1; SgIgSF; Spermatogenic immunoglobulin superfamily; Synaptic cell adhesion molecule; SynCAM; truncated CADM1 protein; TSLC-1; TSLC1/Nectin-like 2/IGSF4; Tumor suppressor in lung cancer 1; Tumor suppressor in lung cancer 1 homolog
基因别名: 2900073G06Rik; 3100001I08Rik; AI987920; BL2; CADM1; IGSF4; IGSF4A; Necl-2; NECL2; RA175; RA175A; RA175B; RA175C; RA175N; SgIGSF; ST17; sTSLC-1; SYNCAM; SynCam1; TSLC1
UniProt ID: (Human) Q9BY67, (Mouse) Q8R5M8, (Rat) Q6AYP5
Entrez Gene ID: (Human) 23705, (Mouse) 54725, (Rat) 363058
liver development
immune system process
apoptotic process
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
multicellular organism development
spermatogenesis
synapse assembly
cell recognition
unidimensional cell growth
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
cell differentiation
susceptibility to natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of cytokine secretion
detection of stimulus
bone development
T cell mediated cytotoxicity
adherens junction organization
activated T cell proliferation
brain development
