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CCKBR (extracellular) Antibody (ACR-042-200UL) in IHC (P)
Expression of Cholecystokinin B receptor in rat stomach - Immunohistochemical staining of paraffin embedded rat stomach sections using Anti-CCKBR (extracellular) Antibody (#ACR-042), (1:100). Cholecystokinin B receptor (brown) is expressed in both parietal cells (black arrows) and in chief cells (red arrows) of the gastric mucosa. Hematoxilin is used as the counterstain.
产品信息
ACR-042-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CETPRIRGTGTRELE, corresponding to amino acid residues 39-53 of mouse Gastrin/cholecystokinin type B receptor, Extracellular, N-terminus
偶联物
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
CCKBR is a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. CCKBR has been reported in brain, colon, pancreas, stomach, thyroid, and various cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CCK(B) receptor; CCK-B receptor; CCK-BR; CCK2 receptor; CCK2-R; CCKB; Cckb receptor; CCKB-R; Cholecystokinin-2 receptor; Cholecystokinin-B; gastrin receptor; Gastrin/cholecystokinin type B receptor; HGNC:1571
基因别名: CCK-B; CCK-BR; CCK2-R; CCK2R; CCKBR; CCKR-2; CCKRB; Cholrec; GASR
UniProt ID: (Human) P32239, (Rat) P30553, (Mouse) P56481
Entrez Gene ID: (Human) 887, (Rat) 25706, (Mouse) 12426
gastric acid secretion
cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
digestion
sensory perception
feeding behavior
cell proliferation
positive regulation of cell proliferation
cholecystokinin signaling pathway
regulation of phosphatidylinositol 3-kinase activity
digestive tract development
gland development
histamine secretion
behavioral defense response
apoptotic process
G-protein coupled receptor signaling pathway
positive regulation of synaptic transmission, GABAergic
response to insulin
estrous cycle
positive regulation of synaptic transmission
regulation of sensory perception of pain
positive regulation of synaptic transmission, glutamatergic
ERK1 and ERK2 cascade
positive regulation of somatostatin secretion
