Invitrogen

CCR1 Polyclonal Antibody

CCR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CCR1 Antibody (PA1-41062) in IHC (P)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded normal human spleen tissue stained with a CD191/CCR1 polyclonal antibody (Product # PA1-41062) (5 µg/mL), peroxidase-conjugate and DAB chromogen. Note granulocyte staining.

CCR1 Antibody in Western Blot, Immunohistochemistry (WB, IHC)

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产品信息

PA1-41062

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-3 µg/mL

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

5 µg/mL

免疫细胞化学 (ICC/IF)

Assay-Dependent

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流式细胞分析 (Flow)

5-10 µL/test

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产品规格

种属反应

Human, Mouse

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to human CCR1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2074018

产品详细信息

Suggested positive control: A375, antigen standard for CCR1 (transient overexpression lysate).

靶标信息

Chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Met-RANTES preserves the blood-brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice.

Fluids and barriers of the CNS

Yan J,Xu W,Lenahan C,Huang L,Ocak U,Wen J,Li G,He W,Le C,Zhang JH,Mo L,Tang J

Published figure using CCR1 polyclonal antibody (Product # PA1-41062) in Immunohistochemistry

Fri Jan 21 00:00:00 EST 2022

Met-RANTES preserves the blood-brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice.

Fluids and barriers of the CNS

Yan J,Xu W,Lenahan C,Huang L,Ocak U,Wen J,Li G,He W,Le C,Zhang JH,Mo L,Tang J

Published figure using CCR1 polyclonal antibody (Product # PA1-41062) in Immunohistochemistry

Fri Jan 21 00:00:00 EST 2022

Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies.

Journal of virology

Li J,Xue L,Wang J,Meng A,Qiao J,Li M,Wang X,Meng L,Ning J,Gao X,Li W,Ma C,Wei L

PA1-41062 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to provide a new target for the development of co-antiviral inhibitors against other components of the host and co-molecular chaperone/HSP90 and provides a scientific basis for the search for effective broad-spectrum antiviral drugs.

Wed Nov 23 00:00:00 EST 2022

CCR1 Activation Promotes Neuroinflammation Through CCR1/TPR1/ERK1/2 Signaling Pathway After Intracerebral Hemorrhage in Mice.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Yan J,Zuo G,Sherchan P,Huang L,Ocak U,Xu W,Travis ZD,Wang W,Zhang JH,Tang J

PA1-41062 was used in Western Blotting to investigate the activation of CCR1 on neuroinflammation in a mouse model of intracerebral hemorrhage (ICH) and the mechanism of CCR1/tetratricopeptide repeat 1 (TPR1)/extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway in CCR1-mediated neuroinflammation.

Wed Jul 01 00:00:00 EDT 2020

Tumor-associated neutrophils suppress antitumor immunity of NK cells through the PD-L1/PD-1 axis.

Translational oncology

Sun R,Xiong Y,Liu H,Gao C,Su L,Weng J,Yuan X,Zhang D,Feng J

PA1-41062 was used in Flow cytometry/Cell sorting to demonstrate that neutrophils can suppress the antitumor immunity of NK cells in tumor-bearing status through the PD-L1/PD-1 axis.

Thu Oct 01 00:00:00 EDT 2020

Tumor-associated neutrophils suppress antitumor immunity of NK cells through the PD-L1/PD-1 axis.

Translational oncology

Sun R,Xiong Y,Liu H,Gao C,Su L,Weng J,Yuan X,Zhang D,Feng J

PA1-41062 was used in Flow cytometry/Cell sorting to demonstrate that neutrophils can suppress the antitumor immunity of NK cells in tumor-bearing status through the PD-L1/PD-1 axis.

Thu Oct 01 00:00:00 EDT 2020

Crosstalk between CCL7 and CCR3 promotes metastasis of colon cancer cells via ERK-JNK signaling pathways.

Oncotarget

Lee YS,Kim SY,Song SJ,Hong HK,Lee Y,Oh BY,Lee WY,Cho YB

PA141062 was used in flow cytometry to study the contribution of CCL7-induced epithelial-mesenchymal transition signaling to the progression and metastasis of colon cancer

Tue Jun 14 00:00:00 EDT 2016

生物信息学

蛋白别名: C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CD191; chemokine (C-C motif) receptor 1; chemokine (C-C) receptor 1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1 alpha R; MIP-1 alphaR; MIP-1alpha-R; RANTES receptor; RANTES-R

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基因别名: CCR1; CD191; CKR-1; CKR1; CMKBR1; CMKR1; HM145; Mip-1a-R; MIP1aR; SCYAR1

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UniProt ID: (Human) P32246, (Mouse) P51675

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Entrez Gene ID: (Human) 1230, (Mouse) 12768

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功能

phosphatidylinositol phospholipase C activity chemokine receptor activity protein binding C-C chemokine receptor activity C-C chemokine binding chemokine (C-C motif) ligand 7 binding chemokine (C-C motif) ligand 5 binding signal transducer activity G-protein coupled receptor activity

参与通路