Invitrogen

CCR2 Polyclonal Antibody, DyLight™ 550

产品信息

PA5-23048

应用

建议稀释比

已发表文章

免疫组化（冰冻） (IHC (F))

Assay-Dependent

免疫细胞化学 (ICC/IF)

1:50

流式细胞分析 (Flow)

1:50

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide made to an N-terminal portion of the mouse CCR2 protein (within residues 20-100).

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偶联物

DyLight™ 550 DyLight™ 550 DyLight™ 550

激发/发射光谱

556/570 nm 查看光谱

形式

Liquid

浓度

0.73 mg/mL

纯化类型

Antigen affinity chromatography

保存液

50mM sodium borate

内含物

0.05% sodium azide

保存条件

4° C, store in dark

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_11153604

靶标信息

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: C-C chemokine receptor type 2; C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR); C-C CKR-2; Cc-ckr2; CCR-2; CD192; CD192 antigen; chemoattractant protein-1 receptor; chemokine (C-C motif) receptor 2; chemokine (C-C) receptor 2; hCG_14621; JE/FIC receptor; MCP-1 receptor; MCP-1-R; Mcp1 receptor; Mcp1r; MIP-1 alphaR; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor

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基因别名: CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R; mJe-r

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UniProt ID: (Human) P41597, (Mouse) P51683

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Entrez Gene ID: (Human) 729230, (Mouse) 12772

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功能