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产品信息
CCR4-401AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Cat,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 1-50 on human C-C chemokine receptor type 4 protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.
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生物信息学
蛋白别名: C-C chemokine receptor 4; C-C chemokine receptor type 4; C-C CKR-4; CCR-4; CD194; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; fusin; K5-5; leukocyte-expressed seven-transmembrane-domain receptor; MGC88293
基因别名: C-C CKR-4; CC-CKR-4; CCR4; CD194; CHEMR1; ChemR13; CKR4; CMKBR4; HGCN:14099; K5-5; LESTR; Sdf1r
UniProt ID: (Human) P51679, (Mouse) P51680
Entrez Gene ID: (Human) 1233, (Rat) 171054, (Mouse) 12773
neuron migration
tolerance induction
chemotaxis
inflammatory response
immune response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
homeostasis of number of cells
chemokine-mediated signaling pathway
response to radiation
response to bacterium
response to antibiotic
positive regulation of positive chemotaxis
signal transduction
