Invitrogen

CCT6A Polyclonal Antibody

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CCT6A Antibody (PA5-101926) in WB

Western blot analysis of CCT6A in HepG2 cell lysate (left lane: treated with the antigen-specific peptide). Samples were incubated with CCT6A polyclonal antibody (Product # PA5-101926).

CCT6A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CCT6A Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-101926

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:50-1:200

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免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human CCT6A(Accession P40227), corresponding to amino acid residues D174-R224.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2851358

产品详细信息

Antibody detects endogenous levels of total CCT6A.

靶标信息

The protein TCP-1 (t complex polypeptide 1) is a subunit of the heterooligomeric complex CCT (chaperonin containing TCP-1) present in the eukaryotic cytosol. The CCT of eukaryotic cytosol is composed of eight different subunit species, TCP-1 alpha, beta, gamma, delta, epsilon, zeta, eta and theta, each encoded by a different gene. Two zeta subunits have been described: TCP-1 zeta (also designated TCP-1 zeta1) and TCP-1 zeta2. TCP-1 subunits are proposed to have independent functions in folding its in vivo substrates, the actins and tubulins. TCP-1 was first identified in the mouse as relevant for tail-less and embryonic lethal phenotypes. Sequences homologous to TCP-1 have been isolated in several other species, and the yeast TCP-1 has been shown to encode a molecular chaperone for Actin and Tubulin. TCP-1 found in mammalian cells and yeast plays an important role in the folding of cytosolic proteins.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Chaperonin-containing tailless complex polypeptide 1 subunit 6A correlates with increased World Health Organization grade, less isocitrate dehydrogenase mutation, and deteriorative survival of astrocytoma patients.

Journal of clinical laboratory analysis

Hu Y,Fu P,Zhao H,Zhang F,Jiang X,Zhao W,Lv P

Published figure using CCT6A polyclonal antibody (Product # PA5-101926) in Immunohistochemistry

Wed Sep 01 00:00:00 EDT 2021

MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility.

Life science alliance

Lahiri S,Aftab W,Walenta L,Strauss L,Poutanen M,Mayerhofer A,Imhof A

PA5-101926 was used in Immunohistochemistry (Paraffin) to use a combinatorial approach on a characterized mouse model of hormone induced male infertility to uncover misregulated pathways.

Mon Mar 01 00:00:00 EST 2021

MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility.

Life science alliance

Lahiri S,Aftab W,Walenta L,Strauss L,Poutanen M,Mayerhofer A,Imhof A

PA5-101926 was used in Immunohistochemistry (Paraffin) to use a combinatorial approach on a characterized mouse model of hormone induced male infertility to uncover misregulated pathways.

Mon Mar 01 00:00:00 EST 2021

生物信息学

蛋白别名: acute morphine dependence related protein 2; Acute morphine dependence-related protein 2; amino acid transport defect-complementing; CCT zeta-1; CCT zeta1; CCT- zeta-1; CCT- zeta1; CCT-zeta-1; Chaperonin containing T-complex polypeptide 1 subunit 6A; chaperonin containing T-complex subunit 6; chaperonin containing TCP-1; chaperonin containing TCP1, subunit 6A (zeta 1); chaperonin subunit 6a (zeta); histidine transp; histidine transport regulator 3; HTR3; T-complex protein 1 subunit zeta; T-complex protein 1, zeta subunit; TCP 1 zeta; TCP-1- zeta; TCP-1-zeta; TCP1 zeta; TCP1- zeta; Tcp20

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基因别名: CCT-zeta; CCT-zeta-1; CCT6; CCT6A; CCTZ; Cctz-1; Cctz1; HTR3; MoDP-2; TCP-1-zeta; TCP20; TCPZ; TTCP20

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UniProt ID: (Human) P40227, (Mouse) P80317

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Entrez Gene ID: (Human) 908, (Mouse) 12466, (Rat) 288620

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功能

protein binding ATP binding protein binding involved in protein folding poly(A) RNA binding unfolded protein binding WD40-repeat domain binding nucleotide binding chaperonin

参与通路

protein folding positive regulation of telomere maintenance via telomerase protein stabilization positive regulation of establishment of protein localization to telomere positive regulation of protein localization to Cajal body positive regulation of telomerase RNA localization to Cajal body binding of sperm to zona pellucida toxin transport