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Invitrogen
CD105 Monoclonal Antibody (3A9)
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
产品信息
MA5-17041
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3A9
抗原
Purified recombinant fragment of human CD105 expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2538513
产品详细信息
MA5-17041 targets CD105 in indirect ELISA, FACS, ICC, IF, IHC, and WB applications and shows reactivity with Human samples.
The MA5-17041 immunogen is purified recombinant fragment of human CD105 expressed in E. Coli.
MA5-17041 detects CD105 which has a predicted molecular weight of approximately 71kDa.
靶标信息
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD105; CD105 antigen; Endoglin; ORW
基因别名: END; ENG; HHT1; ORW1
UniProt ID: (Human) P17813
Entrez Gene ID: (Human) 2022
transmembrane signaling receptor activity
transforming growth factor beta receptor, cytoplasmic mediator activity
type II transforming growth factor beta receptor binding
protein binding
galactose binding
glycosaminoglycan binding
type I transforming growth factor beta receptor binding
BMP binding
protein homodimerization activity
activin binding
transforming growth factor beta binding
transmembrane signal receptor
chronological cell aging
patterning of blood vessels
vasculogenesis
positive regulation of protein phosphorylation
heart looping
sprouting angiogenesis
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
cell migration involved in endocardial cushion formation
regulation of transcription, DNA-templated
cell adhesion
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
negative regulation of cell migration
BMP signaling pathway
positive regulation of BMP signaling pathway
negative regulation of protein autophosphorylation
dorsal aorta morphogenesis
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
endocardial cushion to mesenchymal transition
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
