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产品信息
MA1-83495
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Non-human primate
已发表种属
Cynomolgus monkey,
Rhesus monkey
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
TF9-10H10
抗原
denatured tissue factor isolated from human brain by the Factor VII affinity method
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS with 0.1M mannitol
内含物
<0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2101347
产品详细信息
This antibody does not react with rabbit.
Mouse anti Human CD142 antibody, clone TF9-10H10 recognizes human CD142, also known as Tissue Factor, is the membrane receptor for coagulation factors VII and VIIa and is the cell surface initiator of coagulation.
靶标信息
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD142; Coagulation factor III; coagulation factor III (thromboplastin, tissue factor); TF; Thromboplastin; Tissue factor
基因别名: CD142; F3; TF; TFA
UniProt ID: (Human) P13726
Entrez Gene ID: (Human) 2152
positive regulation of endothelial cell proliferation
activation of plasma proteins involved in acute inflammatory response
activation of blood coagulation via clotting cascade
activation of cysteine-type endopeptidase activity involved in apoptotic process
aging
blood coagulation
blood coagulation, extrinsic pathway
response to temperature stimulus
response to mechanical stimulus
positive regulation of platelet-derived growth factor receptor signaling pathway
positive regulation of smooth muscle cell migration
protein processing
cytokine-mediated signaling pathway
positive regulation of cell migration
response to estradiol
response to lipopolysaccharide
response to fluid shear stress
positive regulation of angiogenesis
positive regulation of positive chemotaxis
positive regulation of protein kinase B signaling
response to low-density lipoprotein particle
cellular response to hydrogen peroxide
